[{"Bold_text": "adverb", "List Items": ["toward or in the higher part of a stream ;against the current."]}, {"Bold_text": "adjective", "List Items": ["directed upstream; situated upstream:an upstream journey; an upstream hideout.", "Commerce.of or relating to the early stages in the operations of a business or industry, as exploration and production in the oil business ( downstream ).", "against or opposite to the direction of transcription, translation, or synthesis of a DNA, RNA, or protein molecule."]}]