<p><strong>Noun</strong></p><ul><li>a change or variation occurring in the course of something.</li><li>interchange or alternation, as of states or things.</li><li>vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.</li><li>regular change or succession of one state or thing to another.</li><li>change; mutation; mutability.</li></ul>