<p><strong>Noun</strong></p><ul><li>A mean, despicable, or vicious person</li><li>Anything considered to be despicable, frustrating, etc. (used as a general expression of contempt or anger): That hurt like a motherfucker!</li><li>A person or thing that is very large, powerful, or impressive: He’s a real motherfucker on guitar</li></ul>