<p><strong>Noun</strong></p><ul><li>A gripping and shaking of right hands by two individuals, such as to symbolize greeting, congratulation, agreement, or farewell: <em>It was a verbal contract, sealed with a firm handshake.</em></li><li>Also handshaking.</li><li><strong>Computers</strong>: An exchange of predetermined signals between networked or linked devices that is made when a connection is initially established or at intervals during data transmission in order to assure proper synchronization (also used attributively): <em>A successful handshake is required between the server and client before the application will launch.</em></li><li>Two handshake signals are exchanged between the computer and the printer—one from each device.</li></ul>